1 OF THE BEST WAY TO RESTORE OUR YOUTH
1 OF THE BEST WAY TO RESTORE OUR YOUTH
Dr David Sinclair always mention NAD+ is so vital to us. In this short clip, Dr Nichola Conlon talks about why boosting NAD level is one of the key to restore our youthfulness in this short clip.
Dr. Nichola Conlon is the CEO and Cofounder of Nuchido, a company with the aim to translate the latest scientific advances in aging research into consumer products that slow, and even reverse, the signs and processes of aging.
Dr Conlon is a molecular biologist specializing in the study of aging as a biologically complex disorder. Nuchido was founded in May 2017. Over recent years, rejuvenation has been scientifically proven, but the pace of these discoveries is far ahead of public awareness. Nuchido’s mission is to bring to market science-based anti-aging products that really work. Products are designed to promote ‘healthspan’ — the proportion of a person’s life that is lived in good health.
The pioneering work of Nuchido Laboratories is supported by an internationally renowned Scientific Advisory Board.
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Restore Our Cells Ability To Make NAD – Nuchido Time+ Supplement https://www.nuchido.com/REVERSEAGING
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DISCLAIMER: Please note that none of the information in this video constitutes health advice or should be substituted in lieu of professional guidance. The video content is purely for informational purposes.
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The question is, how to boost NAD into the cells, since so called "NAD boosters" are not effective or toobig to enter the cell.
This doctor explains so well!
Why not just take Niacin? I’ve read studies indicate it significantly boosts NAD.
Technically, repairing nampt nad salvage pathways is better.
David Sinclair and youtube channels like this one has led everyone astray. Exercise is likely more effective than NAD booster supplements for boosting and utilizing NAD. (See references below) It seems silly to push NAD booster supplements which have little proof with respect to improving health span, no good proof with respect to reducing mortality, and little proof with increasing NAD in tissue in Humans. Exercise is proven in all of these areas
In this first paper it was reported by a third party that NAD+ was more than doubled in muscle cells following ten weeks of resistance training, restoring levels in older people to that of college-aged individuals.
Lamb DA, Moore JH, Mesquita PHC, Smith MA, Vann CG, Osburn SC, Fox CD, Lopez HL, Ziegenfuss TN, Huggins KW, Goodlett MD, Fruge AD, Kavazis AN, Young KC, Roberts MD. Resistance training increases muscle NAD+ and NADH concentrations as well as NAMPT protein levels and global sirtuin activity in middle-aged, overweight, untrained individuals. Aging (Albany NY). 2020
"While there was a considerable difference in NAD+ levels between the young adults and the normally active older adults, trained older adults were almost on par with the young group. The physically impaired older adults fared the worst, with the lowest levels of NAD+ recorded. The researchers also plotted NAD+ levels against physical activity in individual participants and found a strong correlation between the two."
In this second paper, it was reported that aerobic exercise training increased NAMPT abundance 12% and 28% in young and older individuals, respectively, whereas resistance exercise training increased NAMPT abundance 25% and 30% in young and in older individuals, respectively. (NAMPT provides the mechanism to recycle NAD in human metabolism so it is not depleted as much) . Incidentally, it was reported that HIIT did not increase NAMPT
de Guia RM, Agerholm M, Nielsen TS, Consitt LA, Søgaard D, Helge JW, Larsen S, Brandauer J, Houmard JA, Treebak JT. Aerobic and resistance exercise training reverses age-dependent decline in NAD+ salvage capacity in human skeletal muscle. Physiol Rep. 2019 Jul;7
Finally, also see:
Source : NAD+ Levels Are Correlated with Physical Activity in Humans
This research confirms what has been long suspected, LifespanIO, by Arkadi Mazin, February 22, 2022
In a study published in Nature Aging, a group of scientists has shown that NAD+ levels are correlated not only with age but with physical activity, with elder athletes rivaling normal young adults
Janssens, G.E., Grevendonk, L., Perez, R.Z. et al. Healthy aging and muscle function are positively associated with NAD+ abundance in humans. Nat Aging 2, 254–263 (2022)
Is that Sheekey?
I take NR which I understand turns into NMN
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Besides Fasting…what protocols should we best follow….
Reverse aging revolution has begun
over priced